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Transdermal drug delivery system
TDDS? A method to directly deliver drug to skin.
Human skin consists of stratum corneum, epidermis, and dermis. The most important function of skin is the protection, or the function of wall, which prevents external hazardious matters including germs, virus, pollutants, and many others from entering a body. A range of TDDS methods(microneedle, micro structure, and fulguration) were developed, which all remain still limited to penetrate into the dermis-often they remain in the outer layer of skin.
One of the body organs, skin takes 15% of a human body weight and it can be extended to about 2 square meter when it is unfolded. Also our bodies are covered with skin.
Understanding the function and structure of this organ is the most effective way to move ahead for anti-aging.
The layers of skin cell consist of about 10 to 15 layers and play a role of protection and moisturizing.
The depth of dermis is 1-4mm, which consists of cellular matrix composed of elastin fiber. In the layer of dermis, there are capillaries and nerve fiber endings.
※ Source: Seoul National University Hospital > Medical Information office > Skin
History of TDDS
TDDS has been already activated for the purpose of disease treatment since ancient Egypt. Then it was first scientifically discov-ered in late 20th century that skin drug delivery has a medical effect for skin improvement and treatment, which led to inventing the technology of delivering drug.
Pre AD
In order to protect and treatment on skin, ancient Egyptians applied oil, fat and herbs onto their skin
1800x ~ 1900s
From the late 19th century to the early 20th century, the experiment, measuring the existence of a corresponding drug from blood and urine after topical application to skin, was actively proceeded. In other words, as a result of this experiment, it was experimentally confirmed that drug can enter a body through skin. The initial concept of drug diffusion patch system was established.
Basic concept of TDDS patch system was established.
※ Graphic source : British Journal of Pharmacology (2015) 172 2179 - 2209