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MICRO NEEDLE
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Microneedle developed from technology of Endoderma
TECHNOLOGY #1_Cross-linked HA
One time application for the long lasting moisturizing effect up to 7 days!!
Liquid type
1 Hour Swelling Ratio: 6x increase
Degraded dramatically after
5 hours
VS
Gel type
1 Hour Swelling Ratio: 25x increase
Maintain Swelling even after 5 hours
* Efficacy can last up to 7 days
depending on the individuals
Hyaluronic acid, HA
Cross-linked hyaluronic acid
TECHNOLOGY #2_Endoderma Microneedle Shape
  • ENDODERMA’S
    Microneedle Shape
    Active Ingredient Delivery Rate
    80% above
Other Companies’ Microneedle
Shape
  • Pyramid Shape
  • Cone Shape
  • Pyramid-rod Shape
The genuine Microneedle of Endoderma designed to completely improve the weaknesses of various conventional TDDS based on the proprietary TDDS can deliver the active ingredients into the skin without pain
Endoderma Microneedle
After having made hundreds of experimental attempts, Endoderma has successfully developed the genuine microneedle that can effectively deliver the active ingredients into the skin through its unique shape and optimal array of microneedle
Does not deform when attached to the skinIt can effectively deliver to the dermis layer.
Optimal shape and size of microneedleTip
cross-section (<10um)
For the best delivery rate (delivery of more than 80% of active ingredients)
Microneedle
Hexagonal array, spacing
For best effect (mechanical strength) + minimum irritation
Microneedle optimal aspect ratio
(250~270µm)
TECHNOLOGY #3_Fully Manufacturing Automated Process
Best Quality Control and Quality Assurance system
By 3D Vision Inspection system
01
02
03
04
05
06
APIs preparation
Prepare active
ingredients
APIs mixing
Mix active ingredients
APIs dispensing
Pour mixed APIs
on mold plate
Deformation
and drying
Remove bubbles and dry
Patch shape
fabrication
Cut dried hydrocolloid
to desired shape
3D Vision Inspection
Check defective
microneedle patch
  • Ingredient mix
  • Dispensing of raw materials
  • Patch shape fabrication unit
  • Line Scanner / 2D 3D Inspection
Microneedle of Endoderma is manufactured by a fully-automated system that focuses on quality and sanitary control for the high quality of the product.
The latest technology of the 2D/3D Vision Inspection System makes comprehensive QA/QC management possible by checking the height, array, and location of microstructures and any possible contaminants in all final products.
Dissolution test after applying Micro Patch
Before application After 10 sec.
After 30 min. After 120 min.